Silencio
Ana Elisa | Farmacologia
O uso de AINEs pode atrapalhar (e muito!) o controle da pressão arterial. Isso acontece porque os AINEs inibem a enzima ciclooxigenase (COX), reduzindo a produção de prostaglandinas, que têm papel fundamental na vasodilatação renal e na manutenção do fluxo sanguíneo nos néfrons. Quando essa via é inibida, há vasoconstrição da arteríola aferente, o que diminui a filtração glomerular e compromete a eficácia de anti-hipertensivos como IECA, BRA e diuréticos tiazídicos. Resultado? Pressão mais difí...
Seguir
2
0
0
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