Mute
Julio Luchmann
O fígado possui um sistema sofisticado de biotransformação de substâncias, geralmente dividido em três fases de metabolização. Na fase 1, enzimas do sistema citocromo P450 transformam toxinas, medicamentos e álcool em moléculas intermediárias mais reativas por meio de reações como oxidação, redução e hidrólise. Essa etapa é essencial para iniciar a degradação das substâncias, mas também pode gerar metabólitos temporariamente mais tóxicos, o que exige que o organismo prossiga rapidamente para as
Follow
163
3
11
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