Mute
Elianapiresmelasma
A melanina é sintetizada nos melanócitos a partir da tirosina, por ação da tirosinase, gerando inicialmente DOPA e, em sequência, dopaquinona. A partir daí, a via segue para a formação de eumelanina ou feomelanina, com posterior transferência dos melanossomas para os queratinócitos. Esse processo não é isolado. Ele é regulado por sinalizações como a-MSH, ativação do receptor MC1R, expressão de MITF e estímulos inflamatórios e oxidativos que aumentam a atividade melanogênica. É aqui que entram os
Follow
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